Too many people forget the key to a great interview: what the interviewer remembers about you.
The vast majority of what happens in any given interview is pretty forgettable...for the interviewer. As the candidate, you have one experience of the interview question. When the interviewer asks about your greatest weakness and you cleverly reframe a strength by saying, "Gosh, Jim, you know sometimes I work too hard." You probably feel like you nailed it.